Even more studies into the biology of manic depression, schizophrenia and diabetes

copyright banner salted lithium photo header

spacer

“…recent studies have shown that genes linked to mental illness are also involved in the generation of circadian rhythms and sleep, while some clock genes have also been shown to influence the development of certain specific mental illnesses. This new insight of common and overlapping mechanisms is not only telling us much about the biology of these processes, but is also informing the development of new treatments for these severely debilitating conditions.”
‘Waking up to the link between a faulty body clock and mental illness’

spacer

“…research, published online in advance of the August issue of the Journal of Clinical Psychopharmacology, involved 30 patients with treatment-resistant schizophrenia who were divided into two groups: one that received famotidine and one that received placebo. Patients receiving the daily dose of famotidine reported decreased symptoms after a week. After a month, the symptoms had decreased by a statistically significant amount.
“Patients receiving placebo reported no change in symptoms”

‘Antihistamine Decreases Schizophrenia Symptoms’

spacer

“The human nose may hold the key to diagnosing schizophrenia, according to a team of US-Israeli researchers. They say that biological markers for the disease exist in nerve cells from the upper nasal cavity near the brain, a discovery that could lead to biological diagnosis for schizophrenia and the development of drugs to treat it.”
‘Sniffing out schizophrenia using nose cell samples’

spacer

“The [photo] series sheds light on individuals who face these problems every day. It also presents the question of what the true definition of “normal” is and whose right is it to claim theirs as universal. [John William] Keedy asks, “Is it possible for a society to have a commonly held idea of what is normal, when few individuals in that society actually meet the criteria for normalcy?””
‘Photographer Reveals the Darkness of Mental Illness with Picture Series’

spacer

“There is mounting evidence linking the toxoplasma parasite to changes in mood or personality even though the infectious agent is widely believed to be completely harmless in more than 80 per cent of infected people.
“A number of studies published in recent years have suggested that toxoplasma infection increases the chances of someone developing serious psychological disturbances, such as schizophrenia and bipolar disorder.”

‘Toxoplasma’s links to schizophrenia, bipolar disorder and increased risk taking’

spacer

“…is our understanding of diabetes right? Could the precursors to diabetes cause obesity, and not the other way around? A look at how assumptions may be leading us to wage the wrong medical war. “
‘Peter Attia: Is the obesity crisis hiding a bigger problem?

spacer

…and now, bask in the idiocy that is Jenny McCarthy:

“Jenny McCarthy is well-known for her thoroughly debunked anti-vaccination claims. She also once claimed she was an “indigo” and her son was a “crystal” child. Those two beliefs may be connected.”
‘Do Jenny McCarthy’s antivax views stem from the indigo child movement?’

spacer

“Several news outlets… are reviewing the [recent] measles outbreak in Wales [and in Ottawa, Canada], citing public health experts who lay the blame for the burst in cases squarely at the feet of Andrew Wakefield’s bogus MMR vaccine scare in 1998 and the subsequent media coverage.
“…[In Wales it] left 1219 people infected with measles and one in ten hospitalized. Most were hospitalized with pneumonia or dehydration, and most fell into the age range of children who should have been vaccinated around the time of the Wakefield scare.”

‘The Price Of The Autism-Measles Panic, 15 Years Later’

.

...thanks.

.

Posted in Bipolar, Bipolar Disease, Bipolar Disorder, crazy people with no pants, Diabetes, Health, Manic Depression, Mental Health, Schizophrenia | Tagged , | 2 Comments

Some studies into the biology of manic depression and schizophrenia

copyright banner salted lithium photo header

spacer

“Certain brain regions in people with major depression are smaller and less dense than those of their healthy counterparts. Now, researchers have traced the genetic reasons for this shrinkage.
“Brain-imaging studies, post-mortem examinations of human brains and animal studies have all found that in depression, a part of the brain called the dorsolateral prefrontal cortex shrinks. The neurons in this region, which is responsible for complex tasks from memory and sensory integration to the planning of actions, are also smaller and less dense in depressed people compared with healthy people.”

‘How Depression Shrinks the Brain’

spacer

“Social isolation in youth may wreak havoc on the brain by disrupting a protein crucial to the development of the nervous system’s support cells, new research finds.
“A new study in mice finds that when the animals are isolated during a crucial early period, brain cells called oligodendrocytes fail to mature properly. Oligodendrocytes build the fatty, insulating sheathes that cushion neurons, and their dysfunction seems to cause long-lasting behavioural changes.
“Some of the myelination changes produced from isolation are also seen in patients with bipolar disorder and schizophrenia, Corfas said, making the project promising for a number of neuropsychiatric disorders.”

‘Mystery of How Social Isolation Messes with Brain Solved’

spacer

“People prone to depression may struggle to organize information about guilt and blame in the brain, new neuroimaging research suggests.
“Crushing guilt is a common symptom of depression, an observation that dates back to Sigmund Freud. Now, a new study finds a communication breakdown between two guilt-associated brain regions in people who have had depression. This so-called “decoupling” of the regions may be why depressed people take small faux pas as evidence that they are complete failures.”

‘Why Some People Blame Themselves for Everything’

spacer

“Schizophrenia symptoms include memory and attention problems, hallucinations, disorganized thinking and behavior and delusions. Psychotic symptoms typically start in late adolescence and early adulthood. But researchers believe that developmental abnormalities they don’t yet know about also increase diabetes risk.
“One recent study – based on data from the Clinical Antipsychotic Trials of Intervention Effectiveness Schizophrenia Trial – showed the prevalence rate of metabolic syndrome, a group of risk factors that include abdominal obesity, high lipid and cholesterol blood levels and insulin resistance, is more than 50 percent in women and about 37 percent in men with schizophrenia.”

‘Diabetes Linked to Schizophrenia’

spacer

“Although less severe, patients with bipolar disorder share many of the same cognitive difficulties as patients with schizophrenia — including problems with identifying facial expressions, emotions and facial gender, according to a new study.
“Past research has shown that people with schizophrenia have clear cognitive deficits with respect to emotional perception.”

‘Bipolar, Schizophrenia Share Similar Emotional Perception Difficulties

spacer

“…researchers collected blood samples from 34 people with schizophrenia or schizoaffective disorder and analyzed them to study their DNA. Each of the participants belonged to families with a history of mental illness. The scientists were focusing on seeking out people with a NPAS3 mutation, they ended up finding one and carried out a series of blood tests on members of that family, including two parents and four adult children.
“Results showed that the mother who has schizophrenia, as well as her two children with the same disorder and another suffering from depression, all shared the same mutant genetic variation of NPAS3. The mutated version of the gene had one single difference in that an isoleucine took the place of a valine. The authors are not yet sure how this change affects the function of the gene, though.”

‘Gene Associated With Schizophrenia Identified

.

...thanks.

.

Posted in Bipolar, Bipolar Disease, Bipolar Disorder, Clinical Depression, crazy people with no pants, Diabetes, Health, Living With Depression, Living With Manic Depression, Manic Depression, Mental Health | Tagged | 7 Comments

Back in a minute.

copyright banner salted lithium photo header

spacer

Turns out moving in with two children, and learning the schedule and eccentricities of another adult, takes time… and patience. And time. So… yeah.

.

...thanks.

.

Posted in Health | 3 Comments

Protected: A short story about someone named Alex

This content is password-protected. To view it, please enter the password below.

Posted in crazy people with no pants, fiction, Health, Living With Depression, Living With Manic Depression, Manic Depression | Enter your password to view comments.

Protected: Something I wrote a long time ago about someone who doesn’t exist (updated)

This content is password-protected. To view it, please enter the password below.

Posted in Bipolar, Bipolar Disease, Bipolar Disorder, Clinical Depression, crazy people with no pants, fiction, Health, Living With Depression, Living With Manic Depression, Manic Depression, Mental Health | Enter your password to view comments.

Moving.

copyright banner salted lithium photo header

spacer

“When I moved from Ottawa to Toronto [in 1998] I had two bags of clothes, some books and a [10-year old] radio. Four or five years later, when I moved [back] I had two bags of clothes, a few more books, a 486 HP computer and the same radio. This, right here, is the longest I’ve ever lived in one place…”
‘The 52 Places I Can Remember Calling Home; October 31, 2007 , Me.

spacer

Diane and I will begin living together in October. The main difference in my life between now and four months from now… noise and responsibility. The two things I hate most in life: noise and responsibility.

It’s something we’ve been discussing, occasionally, over the past year… she asked last year and I’ve been putting it off.

The problem, for me, has always been money. I asked my ODSP worker last year what would happen if I moved in with my girlfriend and, through his thick, regional French accent, all I heard was “…you’re boned. Half your cheque is taken away, then we tie raw meat to your genitals and release the half-starved rats.”

I finally went back a few weeks ago and had someone at the ODSP office explain the process to me, very slowly and using diagrams. On a bureaucratic level it still makes no sense to me, but I understand the process better now.

Because bureaucracy is inherently evil, if (when) I move in with my girlfriend, the government will take $0.50 off my monthly cheque for every $1 she makes, net.

Does that make sense? Not to me. Why am I being punished for living with my girlfriend, and why is she being punished for living with me?

If we don’t live together, I receive $1,036 through my disability pension.

If we do live together, because she makes minimum wage, I’ll only receive $600 (+/-).

That means, either she’ll be paying my rent every month, or buying all the groceries. Either way, I’m a burden on my minimum wage income girlfriend.

But the Ontario government would be paying my $1,036 if we were never to live together. So the incentive, financially, is to not live together. In which case, the government pays me $1,036.

Does that make sense? That they’d create a system where it makes more financial sense for us to live separately?

They used to have the same system for two people on ODSP who moved in together — in that case both their cheques would be cut and, basically, the two people would receive one cheque. But, either last year or the year before, they stopped doing that.

So now, two disabled people can live together and receive two full incomes.

But, because my girlfriend works in a factory for minimum wage, we can’t.

However… from the minute we’re living together the ODSP system will consider us to be ‘common law’. Which means… from day one she, and the two boys, will be covered under my dental plan, under my drug plan and all of the other ‘perks’ of being disabled in Ontario.

Like a pair of free eyeglasses every two years.

We’ve already made appointments with the dentist for Diane and the boys. Diane needs a root canal done, which would cost $1,200 under her current ‘too poor to have any health insurance’ plan. Right now she’s treating it with Advil and antibiotics. But, with the two of us living together, she’ll be able to go to the dentist four times a year, and have all the fillings she desires — you get a filling, you get a filling, everybody gets a filling!

We’re pretty sure her oldest son is going to need braces. His huge front teeth are coming in, and they look crooked to me. So, living together, we can get the work done.

There are also little weird bonuses that we’d get. Like ODSP will give Diane $100 for having a minimum wage job (!?).

Basically, with the money taken off, and the bonuses applied, I’ll be receiving $860 (+/- but mostly -).

So, once I had all of that explained to me, it just made sense. So I asked Diane if it’s what she wanted, she said yes, and I gave my notice to my landlord last week.

I’ve never lived with a partner… roommates, yes — alcoholic ones, one that huffed aerosols, one that waved a carving knife in my face — but I’ve never asked a woman I was dating to move in with me.

This will be my 53rd address. It’s a nice little place, there are two full-sized bedrooms, then a little half-sized one that I’ll be using as an office. There’s a full, mostly finished basement, half of which is set up for the kids as a play area. The rest is for storage and laundry. There’s also a secluded backyard that turns into a thicket of trees.

The only condition I laid out was that Diane’s relationship with her oldest son had to improve. I actually made that a condition a few months ago, and they are getting along better.

Diane’s a great mother, but she has some behaviours she learned while being abused by her parents. She yells, but when I tell her she’s yelling, she automatically stops yelling and says “I’m not yelling”. To her it’s ‘talking loudly’. And she’s right, she’s not ‘yelling’ yelling, but her ‘talking loudly’ is aggressive and angry. Her father does the same thing… he yells, all the fucking time. But when I called him on it, he dropped it and said “I’m not yelling”.

She also gets aggressive when she’s pissed at her oldest son. Like, she’ll stand right in front of him while she’s telling him “it’s not nice” to do whatever. To a tiny 6-year old that’s like having God standing there, telling you there’s no Heaven for you.

But I explained all of that to her. And she has gotten better. Much better.

I am apprehensive about this, mostly because I’ve got a great apartment right now — the windows are falling out, there’s no insulation and the toilet runs constantly, but it’s cheaper than dirt, and I can see mountains and a river and trees and rooftops from my balcony. I can also kick everyone out on a whim and have an entire, quiet, apartment to myself for as long as I want.

Having never lived with a partner before, I’m assuming I won’t be allowed to that.

Plus, I’ve lived here for almost eight years. Before living here, the average time I’d ever lived anywhere was less than six months.

…shit just got real, y’all.

.

...thanks.

.

Posted in Bipolar, Clinical Depression, crazy people with no pants, Health, Lithium, Living With Depression, Living With Manic Depression, Manic Depression, Mental Health, Poverty | 8 Comments